Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …

The influenza virus is a global threat to human health causing unpredictable yet recurring
pandemics, the last four emerging over the course of a hundred years. As our knowledge of …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

Infectious virus outbreaks pose a significant challenge to public healthcare systems. Early
and accurate virus diagnosis is critical to prevent the spread of the virus, especially when no …

Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …

Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

With the constant threat of emergence of a novel influenza virus pandemic, there must be
continued evaluation of the molecular mechanisms that contribute to virulence. Although the …

Emerging evidence indicates a central role for the microbiome in immunity. However, causal
evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy …

The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …