AI-powered microfluidics: sha** the future of phenotypic drug discovery

J Liu, H Du, L Huang, W **e, K Liu… - … Applied Materials & …, 2024 - ACS Publications
Phenotypic drug discovery (PDD), which involves harnessing biological systems directly to
uncover effective drugs, has undergone a resurgence in recent years. The rapid …

Imaging technologies for microfluidic biochips

J Han, U Kang, EY Moon, H Yoo, B Gweon - BioChip Journal, 2022 - Springer
With the growing interest in biochips, numerous efforts have been made to recapitulate a
more reliable and physiologically relevant environment within chips, resulting in significant …

Trends in hyperspectral imaging: from environmental and health sensing to structure-property and nano-bio interaction studies

EM Rodrigues, E Hemmer - Analytical and Bioanalytical Chemistry, 2022 - Springer
Hyperspectral imaging (HSI) is a technique that allows for the simultaneous acquisition of
both spatial and spectral information. While HSI has been known for years in the field of …

Technological advances in tumor-on-chip technology: From bench to bedside

S Bērziņa, A Harrison, V Taly, W **ao - Cancers, 2021 - mdpi.com
Simple Summary Various 3D in vitro tumor models are rapidly advancing cancer research.
Unlike animal models, they can be produced quickly and are amenable to high-throughput …

Advanced devices for tumor diagnosis and therapy

L Wang, C Dai, L Jiang, G Tong, Y **ong, K Khan… - Small, 2021 - Wiley Online Library
At present, tumor diagnosis is performed using common procedures, which are slow, costly,
and still presenting difficulties in diagnosing tumors at their early stage. Tumor therapeutic …

Carboplatin sensitivity in epithelial ovarian cancer cell lines: The impact of model systems

B Patra, MA Lateef, MN Brodeur, H Fleury… - PLoS …, 2020 - journals.plos.org
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America,
underscoring the need for the development of new therapeutic strategies for the …

Live-cell fluorescence spectral imaging as a data science challenge

JP Acuña-Rodriguez, JP Mena-Vega… - Biophysical …, 2022 - Springer
Live-cell fluorescence spectral imaging is an evolving modality of microscopy that uses
specific properties of fluorophores, such as excitation or emission spectra, to detect multiple …

Microfluidic Techniques for Next‐Generation Organoid Systems

J Gong, M Li, J Kang, Z Yin, Z Cha… - Advanced Materials …, 2022 - Wiley Online Library
Organoids are 3D multicellular structures derived from pluripotent stem cells (PSCs) or adult
stem cells (ASCs), which have attracted increasing interest in the fields of drug screening …

Analysis of cellular response to drugs with a microfluidic single-cell platform based on hyperspectral imaging

L Liu, L Zhang, X Zhang, X Dong, X Jiang, X Huang… - Analytica Chimica …, 2024 - Elsevier
Background Cellular response to pharmacological action of drugs is significant for drug
development. Traditional detection method for cellular response to drugs normally rely on …

Radiotherapy on-chip: microfluidics for translational radiation oncology

R Chermat, M Ziaee, DY Mak, E Refet-Mollof, F Rodier… - Lab on a Chip, 2022 - pubs.rsc.org
The clinical importance of radiotherapy in the treatment of cancer patients justifies the
development and use of research tools at the fundamental, pre-clinical, and ultimately …