Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder associated with
hyperandrogenism and anovulation. Although a spectrum disorder, many women with …

Polycystic ovary syndrome (PCOS) is a prevalent and distressing disorder of largely
unknown etiology. Although PCOS defined by ovarian dysfunction, accumulating evidence …

In rodents, the ovulation-inducing luteinizing hormone (LH) surge is sexually dimorphic,
occurring only in females, but the reasons for this sex difference are unclear. Two …

Kisspeptin is the most potent stimulator of LH release. There are two kisspeptin neuronal
populations in the rodent brain: in the anteroventral periventricular nucleus (AVPV) and in …

Fertility relies upon pulsatile release of gonadotropin-releasing hormone (GnRH) that drives
pulsatile luteinizing hormone secretion. Kisspeptin (KP) neurons in the arcuate nucleus are …

Pregnancy is energetically demanding and therefore, by necessity, reproduction and energy
balance are inextricably linked. With insufficient or excessive energy stores a female is liable …

Since its discovery as a novel gonadotropin inhibitory peptide in 2000, the central and
peripheral roles played by gonadotropin-inhibiting hormone (GnIH) have been significantly …

Epilepsy is a common chronic neurological disease that manifests as recurrent seizures.
The incidence and prevalence of epilepsy in women are slightly lower than those in men …

Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted
endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad …

Kisspeptin has an indispensable role in gonadotropin-releasing hormone/gonadotropin
secretion in mammals. In rodents, kisspeptin neurons are located in distinct brain regions …