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Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune …
Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …
Metabolic reprogramming and epigenetic modifications on the path to cancer
L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis
D Yuan, J Chu, H Lin, G Zhu, J Qian, Y Yu… - Frontiers in …, 2023 - frontiersin.org
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression
Abstract Acylphosphatase 1 (ACYP1), a protein located in the mammalian cell cytoplasm,
has been shown to be associated with tumor initiation and progression by functioning as a …
has been shown to be associated with tumor initiation and progression by functioning as a …
[HTML][HTML] Transsulfuration, minor player or crucial for cysteine homeostasis in cancer
Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing
biomolecules that control multiple essential cellular activities. Altered cysteine metabolism …
biomolecules that control multiple essential cellular activities. Altered cysteine metabolism …
m6A methylation: a process resha** the tumour immune microenvironment and regulating immune evasion
X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
One-carbon metabolism is an essential branch of cellular metabolism that intersects with
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …
Targeting methionine metabolism in cancer: opportunities and challenges
P Bin, C Wang, H Zhang, Y Yan, W Ren - Trends in Pharmacological …, 2024 - cell.com
Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis.
Recent studies have revealed mechanisms regulating methionine metabolism within the …
Recent studies have revealed mechanisms regulating methionine metabolism within the …