The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Because more and more men are being diagnosed with prostate cancer worldwide,
knowledge about and prevention of this disease is important. Epidemiological studies have …

Hormone-related cancers, namely breast, endometrium, ovary, prostate, testis, thyroid and
osteosarcoma, share a unique mechanism of carcinogenesis. Endogenous and exogenous …

Prostate cancer is the most commonly diagnosed cancer in western men, and incidence is
rising rapidly in most countries, including low‐risk populations. Age‐adjusted incidence and …

[Frontiers in Bioscience 11, 1388-1413, May 1, 2006] 1388 Prostate cancer epidemiology Ann
W. Hsing 1 and Anand P. Chokkalingam Page 1 [Frontiers in Bioscience 11, 1388-1413, May 1 …

T is now well accepted that serum testosterone (T) levels decline progressively with aging in
men (1–5). This decline is associated with alterations in body composition; diminished …

It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis,
presence of phenocopies within high-risk pedigrees and genetic complexity. A genome …

BACKGROUND Although narrative reviews have concluded that there is strong support for
familial clustering of prostate carcinoma, the association has never systematically been …

Beyond sexual functions, androgens exert their action in skin physiology and
pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or …

Over 200,000 new prostate cancer cases are diagnosed in the United States each year,
accounting for more than 35% of all cancer cases affecting men, and resulting in 40,000 …