With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related
progressive disease characterized by reduced bone mass and increased risk of fractures. At …

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

Methyltransferase-like 3 (METTL3) is the main enzyme for N 6-methyladenosine (m 6 A)-
based methylation of RNAs and it has been implicated in many biological and …

Background: Under the transcriptional control of numerous factors and intracellular signals,
mesenchymal stem cells (MSCs) can differentiate into various cell types, including …

Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to
other types of cell death. Elucidating additional mechanisms that govern cancer cell death is …

Osteoporosis and obesity result from disturbed osteogenic and adipogenic differentiation
and present emerging challenges for our aging society. Because of the regulatory role of …

Balanced differentiation of mesenchymal stromal cells (MSCs) into osteoblasts and
adipocytes is essential for healthy bone and fat homeostasis. A disturbed balance of MSC …