Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …

The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …

Abstract Analysis of publicly available genomic and gene expression data demonstrates that
MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl …

The development of BH3 mimetics, which antagonize prosurvival proteins of the BCL-2
family, represents a potential breakthrough in cancer therapy. Targeting the prosurvival …

Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key
regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human …

Protein–protein interactions (PPIs) are fundamental to many biological processes that play
an important role in the occurrence and development of a variety of diseases. Targeting the …

TP53 wild-type breast tumors rarely undergo a complete pathological response after
chemotherapy treatment. These patients have an extremely poor survival rate and studies …

Mitochondria in addition to be a main cellular power station, are involved in the regulation of
many physiological processes, such as generation of reactive oxygen species, metabolite …

Breast cancer (BC) is a leading cause of death in women worldwide and multidrug
resistance (MDR) severely limits its treatment since chemotherapy is the standard approach …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …