A review on forced degradation strategies to establish the stability of therapeutic peptide formulations
Peptides are small polymers composed of 40 or fewer amino acids and are an increasingly
important class of drugs. Therapeutic peptides are less immunogenic and more economical …
important class of drugs. Therapeutic peptides are less immunogenic and more economical …
HP-β-CD for the formulation of IgG and Ig-based biotherapeutics
HH Wu, P Garidel, B Michaela - International Journal of Pharmaceutics, 2021 - Elsevier
The main challenge to develop HCF for IgG and Ig-based therapeutics is to achieve
essential solubility, viscosity and stability of these molecules in order to maintain product …
essential solubility, viscosity and stability of these molecules in order to maintain product …
Preparation and characterization of endolysin-containing liposomes and evaluation of their antimicrobial activities against gram-negative bacteria
The overuse and misuse of antibiotics in treating bacterial infections cause the rapid
emergence of drug-resistant bacteria, suggesting that the development of alternative …
emergence of drug-resistant bacteria, suggesting that the development of alternative …
Effect of whole tomato powder or tomato peel powder incorporation on the color, nutritional, and textural properties of extruded high moisture meat analogues
Soy protein based high moisture meat analogues (HMMAs) were made by extrusion, with
incorporation of 0, 5, 10, and 20% whole tomato powder (WTP) or 10% tomato peel powder …
incorporation of 0, 5, 10, and 20% whole tomato powder (WTP) or 10% tomato peel powder …
A glucose tolerant β-glucosidase from Thermomicrobium roseum that can hydrolyze biomass in seawater
β-Glucosidase (EC 3.2. 1.21) plays an essential role in the hydrolysis of the β-1, 4 linkage of
cellobiose. Accumulated glucose during saccharification leads to the inhibition of the …
cellobiose. Accumulated glucose during saccharification leads to the inhibition of the …
Gelation: The role of sugars and polyols on gelatin and agarose
S Shimizu, N Matubayasi - The Journal of Physical Chemistry B, 2014 - ACS Publications
Gelation is enhanced by the addition of sugars and polyols. How, at a microscopic level, do
such cosolvents enhance gelation? The following two different hypotheses have been …
such cosolvents enhance gelation? The following two different hypotheses have been …
Unveiling the impact of additives on structural integrity, thermal and color stability of C-phycocyanin–Agar hydrocolloid
C-Phycocyanin and sugar (C-PC/S) blended agar hydrocolloid was prepared and its
rheological, thermo-functional and morphological properties were examined based on the …
rheological, thermo-functional and morphological properties were examined based on the …
An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states
Macromolecular crowding ought to stabilize folded forms of proteins, through an excluded
volume effect. This explanation has been questioned and observed effects attributed to …
volume effect. This explanation has been questioned and observed effects attributed to …
Statistical-Mechanics Analyses on Thermodynamics of Protein Folding Constructed by Privalov and Co-Workers
M Inoue, T Hayashi, S Yasuda, M Kato… - The Journal of …, 2024 - ACS Publications
Privalov and co-workers estimated the changes in hydration enthalpy and entropy upon
ubiquitin unfolding and their temperature dependences denoted by Δ H hyd (T) and Δ S hyd …
ubiquitin unfolding and their temperature dependences denoted by Δ H hyd (T) and Δ S hyd …
Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere solvent and …
H Oshima, M Kinoshita - The Journal of chemical physics, 2015 - pubs.aip.org
In earlier works, we showed that the entropic effect originating from the translational
displacement of water molecules plays the pivotal role in protein folding and denaturation …
displacement of water molecules plays the pivotal role in protein folding and denaturation …