A review on forced degradation strategies to establish the stability of therapeutic peptide formulations

S Patel, VK Vyas, PJ Mehta - International Journal of Peptide Research …, 2023 - Springer
Peptides are small polymers composed of 40 or fewer amino acids and are an increasingly
important class of drugs. Therapeutic peptides are less immunogenic and more economical …

HP-β-CD for the formulation of IgG and Ig-based biotherapeutics

HH Wu, P Garidel, B Michaela - International Journal of Pharmaceutics, 2021 - Elsevier
The main challenge to develop HCF for IgG and Ig-based therapeutics is to achieve
essential solubility, viscosity and stability of these molecules in order to maintain product …

Preparation and characterization of endolysin-containing liposomes and evaluation of their antimicrobial activities against gram-negative bacteria

J Bai, E Yang, PS Chang, S Ryu - Enzyme and microbial technology, 2019 - Elsevier
The overuse and misuse of antibiotics in treating bacterial infections cause the rapid
emergence of drug-resistant bacteria, suggesting that the development of alternative …

Effect of whole tomato powder or tomato peel powder incorporation on the color, nutritional, and textural properties of extruded high moisture meat analogues

X Lyu, D Ying, P Zhang, Z Fang - Food and Bioprocess Technology, 2024 - Springer
Soy protein based high moisture meat analogues (HMMAs) were made by extrusion, with
incorporation of 0, 5, 10, and 20% whole tomato powder (WTP) or 10% tomato peel powder …

A glucose tolerant β-glucosidase from Thermomicrobium roseum that can hydrolyze biomass in seawater

SK Sinha, M Datta, S Datta - Green Chemistry, 2021 - pubs.rsc.org
β-Glucosidase (EC 3.2. 1.21) plays an essential role in the hydrolysis of the β-1, 4 linkage of
cellobiose. Accumulated glucose during saccharification leads to the inhibition of the …

Gelation: The role of sugars and polyols on gelatin and agarose

S Shimizu, N Matubayasi - The Journal of Physical Chemistry B, 2014 - ACS Publications
Gelation is enhanced by the addition of sugars and polyols. How, at a microscopic level, do
such cosolvents enhance gelation? The following two different hypotheses have been …

Unveiling the impact of additives on structural integrity, thermal and color stability of C-phycocyanin–Agar hydrocolloid

VS Rekha, K Sankar, S Rajaram, P Karuppiah… - Food Chemistry, 2024 - Elsevier
C-Phycocyanin and sugar (C-PC/S) blended agar hydrocolloid was prepared and its
rheological, thermo-functional and morphological properties were examined based on the …

An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states

C Alfano, D Sanfelice, SR Martin, A Pastore… - Nature …, 2017 - nature.com
Macromolecular crowding ought to stabilize folded forms of proteins, through an excluded
volume effect. This explanation has been questioned and observed effects attributed to …

Statistical-Mechanics Analyses on Thermodynamics of Protein Folding Constructed by Privalov and Co-Workers

M Inoue, T Hayashi, S Yasuda, M Kato… - The Journal of …, 2024 - ACS Publications
Privalov and co-workers estimated the changes in hydration enthalpy and entropy upon
ubiquitin unfolding and their temperature dependences denoted by Δ H hyd (T) and Δ S hyd …

Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere solvent and …

H Oshima, M Kinoshita - The Journal of chemical physics, 2015 - pubs.aip.org
In earlier works, we showed that the entropic effect originating from the translational
displacement of water molecules plays the pivotal role in protein folding and denaturation …