Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS),
characterized by intense proteinuria leading to edema and intravascular volume depletion …

Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …

Rituximab induces nephrotic syndrome (NS) remission in two-thirds of patients with primary
membranous nephropathy (MN), even after other treatments have failed. To assess the …

Background Rituximab could be an effective treatment for childhood-onset, complicated,
frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic …

Background Long-term outcomes after multiple courses of rituximab among children with
frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) are unknown …

The pathogenesis of nephrotic syndrome is unclear. However, the efficacy of rituximab, a B
cell–depleting antibody, in nephrotic syndrome suggests a pathogenic role of B cells. In this …

Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or
steroid-sparing agents. This open-label, noninferiority, randomized controlled trial at four …

Importance Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy
for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B …

The pathogenesis of idiopathic nephrotic syndrome (INS) is as yet unknown, but several
lines of evidence indicate that the immune system may play a crucial pathogenic role in non …

Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children.
At least 20% of children with this syndrome show frequent relapses and/or steroid …