Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue
inflammation. The innate immune system is the front line of host defense in which innate …

Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including
discrimination between self-and non-self-antigens, containment of immunopathology, and …

The T cell repertoire of healthy mice and humans harbors self-reactive CD4+ conventional T
(Tconv) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with in …

Conventional dendritic cells expressing the XCR1 chemokine receptor (cDC1s) excel at
cross-presentation. Here, we developed and used a mouse model in which a Cre …

Conventional CD4+ and CD8+ T lymphocytes comprise a mixture of naive and memory
cells. Generation and survival of these T-cell subsets is under strict homeostatic control and …

The key role of T cells in cancer immunotherapy is well established and is highlighted by the
remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion …

Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune
and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). We …

Injection of Interleukin-2 (IL-2) complexed with a particular anti–IL-2 monoclonal antibody
(mab) JES6-1 has been shown to selectively expand CD4+ Foxp3+ T regulatory T cells …

Conventional CD4+ T lymphocytes consist of naïve, foreign antigen-specific memory, and
self-antigen-driven memory-phenotype (MP) cell compartments at homeostasis. We recently …

In conventional adaptive immune responses, upon recognition of foreign antigens, naive
CD4+ T lymphocytes are activated to differentiate into effector/memory cells. In addition …