[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …

MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

[HTML][HTML] Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

[HTML][HTML] A review of the proteomic profiling of African Viperidae and Elapidae snake venoms and their antivenom neutralisation

BC Offor, B Muller, LA Piater - Toxins, 2022 - mdpi.com
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection
of snake venom of a venomous snake into animals and humans. In Africa (mainly in sub …

Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors

GH Sampat, K Hiremath, J Dodakallanavar… - Pharmacological …, 2023 - Springer
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported
approximately 5 million people are bitten by various species of snakes each year, resulting …

Differential effects of the venoms of Russell's viper and Indian cobra on human myoblasts

H Bin Haidar, JR Almeida, J Williams, B Guo, A Bigot… - Scientific reports, 2024 - nature.com
Local tissue damage following snakebite envenoming remains a poorly researched area. To
develop better strategies to treat snakebites, it is critical to understand the mechanisms …

Pharmacological re-assessment of traditional medicinal plants-derived inhibitors as antidotes against snakebite envenoming: A critical review

U Puzari, PA Fernandes, AK Mukherjee - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Traditional healers have used medicinal plants to treat
snakebite envenomation worldwide; however, mostly without scientific validation. There …

The design and discovery of phospholipase A2 inhibitors for the treatment of inflammatory diseases

CS Batsika, ADD Gerogiannopoulou… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

Recent advancements in snake antivenom production

AS Rathore, R Kumar, OS Tiwari - International journal of biological …, 2023 - Elsevier
Snakebite envenoming (SBE), a neglected tropical disease, claims lives of about 138,000
people globally, and antivenom is the only approved treatment worldwide. However, this …

[HTML][HTML] Characterisation of the forest cobra (Naja melanoleuca) venom using a multifaceted mass spectrometric-based approach

CR Wang, AC Harlington, MF Snel… - Biochimica et Biophysica …, 2024 - Elsevier
Snake venoms consist of highly biologically active proteins and peptides that are
responsible for the lethal physiological effects of snakebite envenomation. In order to guide …