Peptides for vaccine development

IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

Predicting epitopes for vaccine development using bioinformatics tools

V Yurina, OR Adianingsih - Therapeutic advances in …, 2022 - journals.sagepub.com
Epitope-based DNA vaccine development is one application of bioinformatics or in silico
studies, that is, computational methods, including mathematical, chemical, and biological …

Analyzing the systems biology effects of COVID-19 mRNA vaccines to assess their safety and putative side effects

R Hajjo, DA Sabbah, A Tropsha - Pathogens, 2022 - mdpi.com
COVID-19 vaccines have been instrumental tools in reducing the impact of SARS-CoV-2
infections around the world by preventing 80% to 90% of hospitalizations and deaths from …
SM Hamed, MM Sakr, GS El-Housseiny, R Wasfi… - Future Science …, 2023 - Taylor & Francis
The understanding of any disease calls for studying specific biological structures called
epitopes. One important tool recently drawing attention and improving efficiency in both …

A Newly Identified Spike Protein Targeted Linear B‐Cell Epitope Based Dissolvable Microneedle Array Successfully Eliciting Neutralizing Activities against SARS …

L Li, Z Zhao, X Yang, Z Su, W Li, S Chen… - Advanced …, 2023 - Wiley Online Library
Vaccination is a cost‐effective medical intervention. Inactivated whole virusor large protein
fragments‐based severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) vaccines …

[HTML][HTML] COVID-19 vaccines: computational tools and development

VC Osamor, E Ikeakanam, JU Bishung… - Informatics in Medicine …, 2023 - Elsevier
The 2019 coronavirus outbreak, also known as COVID-19, poses a serious threat to global
health and has already had widespread, devastating effects around the world. Scientists …

[HTML][HTML] Computational construction of a glycoprotein multi-epitope subunit vaccine candidate for old and new South-African SARS-CoV-2 virus strains

OO Oluwagbemi, EK Oladipo, EO Dairo… - Informatics in Medicine …, 2022 - Elsevier
The discovery of a new SARS-CoV-2 virus strain in South Africa presents a major public
health threat, therefore contributing to increased infections and transmission rates during the …

Engineering receptor-binding domain and heptad repeat domains towards the development of multi-epitopes oral vaccines against SARS-CoV-2 variants

NF Arshad, FJ Nordin, LC Foong, LLA In, MYM Teo - Plos one, 2024 - journals.plos.org
The inability of existing vaccines to cope with the mutation rate has highlighted the need for
effective preventative strategies for COVID-19. Through the secretion of immunoglobulin A …

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

JA Chick, NN Abongdia, RA Shey, TO Apinjoh - Heliyon, 2025 - cell.com
Malaria, a tropical disease, claims the lives of thousands of people annually and the
development of resistance to insecticides and antimalarial drugs poses a great challenge to …

A new epitope selection method: application to design a multi-valent epitope vaccine targeting hras oncogene in squamous cell carcinoma

K Savsani, G Jabbour, S Dakshanamurthy - Vaccines, 2021 - mdpi.com
We developed an epitope selection method for the design of MHC targeting peptide
vaccines. The method utilizes predictions for several clinical checkpoint filters, including …