The development of cancer begins with cells transitioning from their multicellular nature to a
state akin to unicellular organisms. This shift leads to a breakdown in the crucial regulators …

The Y chromosome has recognized functions in promoting male sex determination and
regulating aspects of fertility. However, recent work has demonstrated important roles for the …

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the phenomenon where a
hematopoietic stem cell acquires fitness-increasing mutation (s), resulting in its clonal …

Simple Summary We were motivated by the need to improve early detection of bladder
cancer (BLCA). Our aim was to uncover genetic alterations within the bladder's lining, called …

Loss of Y chromosome (LOY) is the most commonly occurring post-zygotic (somatic)
mutation in male individuals. The past decade of research suggests that LOY has important …

Mosaic loss of Y chromosome (mLOY) is an acquired condition wherein a sizeable
proportion of an organ's cells have lost their Y. Large-scale cohort studies have shown that …

Clonal haematopoiesis (CH)–the ubiquitous expansion of variants in blood with age–is a
prime example of ongoing somatic evolution in otherwise normal human tissues. The details …

Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …

Somatic mutations acquired in haematopoietic stem cells can drive clonal expansions, a
phenomenon called clonal haematopoiesis (CH). CH has been associated with higher risk …

Mosaic loss of the Y chromosome (mLOY) is the most common somatic event in men,
strongly associated with aging and various health conditions. Current methods for detecting …