Legionnaires' Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella

S Mondino, S Schmidt, M Rolando… - Annual Review of …, 2020 - annualreviews.org
Legionella species are environmental gram-negative bacteria able to cause a severe form of
pneumonia in humans known as Legionnaires' disease. Since the identification of …

Legionella and Coxiella effectors: strength in diversity and activity

J Qiu, ZQ Luo - Nature Reviews Microbiology, 2017 - nature.com
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …

The ubiquitin–proteasome system in immune cells

G Çetin, S Klafack, M Studencka-Turski, E Krüger… - Biomolecules, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

D Burstein, F Amaro, T Zusman, Z Lifshitz, O Cohen… - Nature …, 2016 - nature.com
Infection by the human pathogen Legionella pneumophila relies on the translocation of∼
300 virulence proteins, termed effectors, which manipulate host cell processes. However …

Chloroplasts at the crossroad of photosynthesis, pathogen infection and plant defense

Y Lu, J Yao - International journal of molecular sciences, 2018 - mdpi.com
Photosynthesis, pathogen infection, and plant defense are three important biological
processes that have been investigated separately for decades. Photosynthesis generates …

The large, diverse, and robust arsenal of Ralstonia solanacearum type III effectors and their in planta functions

D Landry, M González‐Fuente… - Molecular Plant …, 2020 - Wiley Online Library
The type III secretion system with its delivered type III effectors (T3Es) is one of the main
virulence determinants of Ralstonia solanacearum, a worldwide devastating plant …

The evolution and pathogenic mechanisms of the rice sheath blight pathogen

A Zheng, R Lin, D Zhang, P Qin, L Xu, P Ai… - Nature …, 2013 - nature.com
Rhizoctonia solani is a major fungal pathogen of rice (Oryza sativa L.) that causes great
yield losses in all rice-growing regions of the world. Here we report the draft genome …

Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

EJ Van Schaik, C Chen, K Mertens… - Nature Reviews …, 2013 - nature.com
The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes
acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two …

Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination

Y Tan, RJ Arnold, ZQ Luo - Proceedings of the National …, 2011 - National Acad Sciences
Effectors delivered into host cells by the Legionella pneumophila Dot/Icm type IV transporter
are essential for the biogenesis of the specialized vacuole that permits its intracellular …

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

Y Tan, ZQ Luo - Nature, 2011 - nature.com
Legionella pneumophila actively modulates host vesicle trafficking pathways to facilitate its
intracellular replication with effectors translocated by the Dot/Icm type IV secretion system …