Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas

D Brandsma, L Stalpers, W Taal, P Sminia… - The lancet …, 2008 - thelancet.com
Since the introduction of chemoradiotherapy with temozolomide as the new standard of care
for patients with glioblastoma, there has been an increasing awareness of progressive and …

Radiation dose–volume effects in the brain

YR Lawrence, XA Li, I El Naqa, CA Hahn… - International Journal of …, 2010 - Elsevier
We have reviewed the published data regarding radiotherapy (RT)-induced brain injury.
Radiation necrosis appears a median of 1–2 years after RT; however, cognitive decline …

Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

MT Makale, CR McDonald… - Nature Reviews …, 2017 - nature.com
Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Pseudoprogression of brain tumors

SC Thust, MJ van den Bent… - Journal of Magnetic …, 2018 - Wiley Online Library
This review describes the definition, incidence, clinical implications, and magnetic
resonance imaging (MRI) findings of pseudoprogression of brain tumors, in particular, but …

Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients-a report of the PET/RANO group

N Galldiks, M Niyazi, AL Grosu, M Kocher… - Neuro …, 2021 - academic.oup.com
The management of patients with glioma usually requires multimodality treatment including
surgery, radiotherapy, and systemic therapy. Accurate neuroimaging plays a central role for …

[PDF][PDF] Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation

C Turnquist, BT Harris, CC Harris - Neuro-oncology advances, 2020 - academic.oup.com
Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …

Diagnosis and management of radiation necrosis in patients with brain metastases

B Vellayappan, CL Tan, C Yong, LK Khor… - Frontiers in …, 2018 - frontiersin.org
The use of radiotherapy, either in the form of stereotactic radiosurgery (SRS) or whole-brain
radiotherapy (WBRT), remains the cornerstone for the treatment of brain metastases (BM) …

Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

U Salem, VA Kumar, JE Madewell, DF Schomer… - Cancer Imaging, 2019 - Springer
MRI-guided laser interstitial thermal therapy (LITT) is the selective ablation of a lesion or a
tissue using heat emitted from a laser device. LITT is considered a less invasive technique …

CNS complications of radiotherapy and chemotherapy

C Soussain, D Ricard, JR Fike, JJ Mazeron… - The lancet, 2009 - thelancet.com
Treatment-induced CNS toxicity remains a major cause of morbidity in patients with cancer.
Advances in the design of safe radiation procedures have been counterbalanced by …

Incidence of early pseudo‐progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide

W Taal, D Brandsma, HG de Bruin, JE Bromberg… - Cancer, 2008 - Wiley Online Library
BACKGROUND. Radiotherapy (RT) plus concomitant and adjuvant temozolomide (TMZ) is
now the standard of care for patients with newly diagnosed glioblastoma. The occurrence of …