Monocytes and macrophages are central cells of the innate immune system, responsible for
defending against diverse pathogens. While they originate from a common myeloid …

Septic syndromes represent a major although largely underrecognized healthcare problem
worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis …

Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

Background Severe sepsis is common and frequently fatal, and community-acquired
pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to …

Rationale: Sustained sepsis-associated immunosuppression is associated with uncontrolled
infection, multiple organ dysfunction, and death. Objectives: In the first controlled biomarker …

Objective: To develop consensus statements for the diagnosis and management of
corticosteroid insufficiency in critically ill adult patients. Participants: A multidisciplinary …

BACKGROUND/AIMS: Cellular immune depression is linked to high mortality in sepsis, but
has yet to be systematically analysed in liver cirrhosis. The aim of the present study was to …

Objective The immediate overwhelming release of inflammatory mediators in septic shock is
rapidly followed by strong anti-inflammatory responses inducing a state of …

Mortality in sepsis remains unacceptably high and attempts to modulate the inflammatory
response failed to improve survival. Previous reports postulated that the sepsis-triggered …

Mera S, Tatulescu D, Cismaru C, Bondor C, Slavcovici A, Zanc V, Carstina D, Oltean M.
Multiplex cytokine profiling in patients with sepsis. APMIS 2010; 119: 155–63. A major goal …