Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics

VK Kashyap, G Peasah-Darkwah, A Dhasmana… - Pharmaceutics, 2022 - mdpi.com
Chemotherapy is one of the prime treatment options for cancer. However, the key issues
with traditional chemotherapy are recurrence of cancer, development of resistance to …

[HTML][HTML] Etiology of lung carcinoma and treatment through medicinal plants, marine plants and green synthesized nanoparticles: A comprehensive review

P Chaudhary, P Janmeda, A Pareek… - Biomedicine & …, 2024 - Elsevier
Lung cancer, a leading global cause of mortality, poses a significant public health challenge
primarily linked to tobacco use. While tobacco contributes to over 90% of cases, factors like …

Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in develo** small molecules of natural origin

D Tewari, A Priya, A Bishayee… - Clinical and …, 2022 - Wiley Online Library
Background Cancer is the world's second leading cause of death, but a significant
advancement in cancer treatment has been achieved within the last few decades. However …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)

A Bashir, M Nabi, N Tabassum, S Afzal… - Frontiers in …, 2023 - frontiersin.org
Withania somnifera (L.) Dunal belongs to the nightshade family Solanaceae and is
commonly known as Ashwagandha. It is pharmacologically a significant medicinal plant of …

[HTML][HTML] Covalent binding of withanolides to cysteines of protein targets

C Bailly - Biochemical Pharmacology, 2024 - Elsevier
Withanolides represent an important category of natural products with a steroidal lactone
core. Many of them contain an α, β-unsaturated carbonyl moiety with a high reactivity toward …

Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect

Y Liang, Q Jiang, H Zou, J Zhao, J Zhang… - Food and Chemical …, 2023 - Elsevier
Glucocorticoids have been widely applied to various clinical treatment, however some
serious side effects may occur during the treatment. It is widely known that glucocorticoids …

Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management

JM Macharia, Z Káposztás, RL Bence - Pharmaceuticals, 2023 - mdpi.com
Research into tumorigenic pathways can aid in the development of more efficient cancer
therapies and provide insight into the physiological regulatory mechanisms employed by …

Ethnological validation of Ashwagandha (Withania somnifera L. Dunal) ghrita as 'Vajikarana Rasayana': In-silico, in-vitro and in-vivo approach

S Gurav, M Wanjari, R Bhole, N Raut, S Prasad… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Processing cow ghee (clarified butterfat) with therapeutic
herbs, ie ghrita, is recognized for augmenting the therapeutic efficacy of plant materials …

Hairy root cultures of Physalis minima L. — an alternative source of withaferin A production

T Halder, B Ghosh - Plant Cell, Tissue and Organ Culture (PCTOC), 2023 - Springer
Physalis minima L. is an important yet underutilised medicinal plant. It has many medicinal
properties, including anticancer activity. This plant synthesizes a crucial steroidal lactone …