The tumor suppressor p53 is critically important in the cellular damage response and is the
founding member of a family of proteins. All three genes regulate cell cycle and apoptosis …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

The role of p53 as a tumour suppressor is generally attributed to its ability to stop the
proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. The relatives …

The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

p73, a member of the p53 family of transcription factors, is upregulated in response to DNA
damage, inducing cell cycle arrest and apoptosis. Besides indications that this p73 response …

Apoptosis and necrosis represent two distinct types of cell death. Apoptosis possesses
unique morphologic and biochemical features which distinguish this mechanism of …

Based on gene sequence homologies, a p53 (TP53) gene family become apparent with the
addition of the most recently identified p63 (TP73L; formerly TP63) and p73 (TP73) genes to …

Dietary flavonoids have been shown to exert specific cytotoxicity towards some cancer cells,
but the precise molecular mechanisms are still not completely understood. In our study …

In this study, cytotoxic effects of structurally related flavones and flavonols on a human
esophageal squamous cell carcinoma cell line (KYSE-510) were determined, and the …

Breast cancer is the second most common malignancy in females worldwide and poses a
great challenge that necessitates the identification of novel therapeutic agents from several …