Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis
YJ Lin, M Anzaghe, S Schülke - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …
The balance of Th1/Th2 cytokines in rheumatoid arthritis
H Schulze-Koops, JR Kalden - Best practice & research Clinical …, 2001 - Elsevier
It has been suggested that rheumatoid inflammation is mediated by activated pro-
inflammatory T helper type I cells. In contrast, immunomodulatory T helper type 2 cells and …
inflammatory T helper type I cells. In contrast, immunomodulatory T helper type 2 cells and …
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We
undertook the present study to identify immune and stromal processes that are present soon …
undertook the present study to identify immune and stromal processes that are present soon …
[HTML][HTML] The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining …
LM Austin, M Ozawa, T Kikuchi, IB Walters… - Journal of Investigative …, 1999 - Elsevier
Psoriasis vulgaris is a skin disease potentially mediated by pro-inflammatory cytokines
produced by type 1 lesional T cells. The capability of individual T cells to produce these …
produced by type 1 lesional T cells. The capability of individual T cells to produce these …
Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium
T Nanki, K Hayashida, HS El-Gabalawy… - The Journal of …, 2000 - journals.aai.org
Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …
The Th1 life cycle: molecular control of IFN-γ to IL-10 switching
Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and
immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not …
immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not …
Interferon-gamma-mediated osteoimmunology
M Tang, L Tian, G Luo, X Yu - Frontiers in immunology, 2018 - frontiersin.org
Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal
and immune systems. They are interconnected by shared signal pathways and cytokines …
and immune systems. They are interconnected by shared signal pathways and cytokines …
Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response
N Luque-Campos, RA Contreras-López… - Frontiers in …, 2019 - frontiersin.org
In the last years, mesenchymal stem cell (MSC)-based therapies have become an
interesting therapeutic opportunity for the treatment of rheumatoid arthritis (RA) due to their …
interesting therapeutic opportunity for the treatment of rheumatoid arthritis (RA) due to their …
Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis …
AI Catrina, C Trollmo, E af Klint… - … : Official Journal of …, 2005 - Wiley Online Library
Objective Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF) antagonists
is highly effective, but their mechanisms of action are not completely clear. Since anti‐TNF …
is highly effective, but their mechanisms of action are not completely clear. Since anti‐TNF …
Th17 cytokines and arthritis
E Lubberts - Seminars in immunopathology, 2010 - Springer
Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA),
although it has not been established whether this persistent destructive arthritis is driven by …
although it has not been established whether this persistent destructive arthritis is driven by …