The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Multidrug evolutionary strategies to reverse antibiotic resistance

M Baym, LK Stone, R Kishony - Science, 2016 - science.org
BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

Futuristic non-antibiotic therapies to combat antibiotic resistance: A review

M Kumar, DK Sarma, S Shubham, M Kumawat… - Frontiers in …, 2021 - frontiersin.org
The looming problem of resistance to antibiotics in microorganisms is a global health
concern. The drug-resistant microorganisms originating from anthropogenic sources and …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults

JS Zifodya, I Schiller, N Dendukuri… - Cochrane Database …, 2019 - cochranelibrary.com
Background Xpert MTB/RIF (Xpert MTB/RIF) and Xpert MTB/RIF Ultra (Xpert Ultra), the
newest version, are the only World Health Organization (WHO)‐recommended rapid tests …

Tackling threats and future problems of multidrug-resistant bacteria

E Medina, DH Pieper - How to overcome the antibiotic crisis: facts …, 2016 - Springer
With the advent of the antibiotic era, the overuse and inappropriate consumption and
application of antibiotics have driven the rapid emergence of multidrug-resistant pathogens …

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

KR Steingart, H Sohn, I Schiller… - Cochrane database …, 2013 - cochranelibrary.com
Background Accurate and rapid detection of tuberculosis (TB) and drug resistance are
critical for improving patient care and decreasing the spread of TB. Xpert® MTB/RIF assay …

Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

M Kohli, I Schiller, N Dendukuri… - Cochrane Database …, 2018 - cochranelibrary.com
Background Tuberculosis (TB) is the world's leading infectious cause of death.
Extrapulmonary TB accounts for 15% of TB cases, but the proportion is increasing, and over …

Drug Resistance Mechanisms in Mycobacterium tuberculosis

JC Palomino, A Martin - Antibiotics, 2014 - mdpi.com
Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by
the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the …