Recombination is a pervasive process generating diversity in most viruses. It joins variants
that arise independently within the same molecule, creating new opportunities for viruses to …

Next generation sequencing (NGS) combined with bioinformatics has successfully been
used in a vast array of analyses for infectious disease research of public health relevance …

Diagnosis and treatment of Plasmodium falciparum infections are required for effective
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …

Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance,. Here …

Summary Background Artemisinin-resistant Plasmodium falciparum has been reported in
Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of …

Widespread use of antimalarial agents can profoundly influence the evolution of the human
malaria parasite Plasmodium falciparum. Recent selective sweeps for drug-resistant …

Strengthening of synaptic connections following coincident pre-and postsynaptic activity was
proposed by Hebb as a cellular mechanism for learning. Contemporary models assume that …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Background The importance of the submicroscopic reservoir of Plasmodium infections for
malaria elimination depends on its size, which is generally considered small in low …