Perturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in
metabolic-dysfunction-associated steatotic liver disease (MASLD), formerly known as …

Protein homeostasis is an essential component of proper cellular function; however,
sustaining protein health is a challenging task, especially during the aerobic lifestyle …

Exposure to excessive sound causes noise-induced hearing loss through complex
mechanisms and represents a common and unmet neurological condition. We investigate …

The threat of global warming makes uncovering mechanisms of plant tolerance to long-term
moderate heat stress particularly important. We previously reported that Arabidopsis …

High‐temperature stress results in protein misfolding/unfolding and subsequently promotes
the accumulation of cytotoxic protein aggregates that can compromise cell survival. Heat …

Most eukaryotic genes encode polypeptides that are either obligate members of hetero-
stoichiometric complexes or clients of organelle-targeting pathways. Proteins in these …

In Saccharomyces cerevisiae cAMP regulates different cellular processes through PKA. The
specificity of the response of the cAMP-PKA pathway is highly regulated. Here we address …

Neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases
affect millions of Americans every year. One factor linked to the formation of aggregates …

We examined the impact of repeated thermal stress on the heat shock response (HSR) of
thermally sensitive lake whitefish (Coregonus clupeaformis) embryos. Our treatments were …

Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin
ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular …