This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …

Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR)
has progressed rapidly in recent times. New crystal structures of the ectodomains with …

Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …

Neuronal transmission relies on the regulated secretion of neurotransmitters, which are
packed in synaptic vesicles (SVs). Hundreds of SVs accumulate at synaptic boutons …

抄録 Quantitative colocalization analysis is an advanced digital imaging tool to examine
antigens of interest in immunofluorescence images obtained using confocal microscopes. It …

Receptor dimerization is important for many signaling pathways. However, the monomer–
dimer equilibrium has never been fully characterized for any receptor with a 2D equilibrium …

The mechanisms by which the diffusion rate in the plasma membrane (PM) is regulated
remain unresolved, despite their importance in spatially regulating the reaction rates in the …

Remarkable progress in optical microscopy has been made in the measurement of
nanometre distances. If diffraction blurs the image of a point object into an Airy disk with a …

Advanced single-molecule fluorescent imaging was applied to study the dynamic
organization of raft-associated glycosylphosphatidylinositol-anchored proteins (GPI-APs) in …

Anomalous subdiffusion has been reported for two-dimensional diffusion in the plasma
membrane and three-dimensional diffusion in the nucleus and cytoplasm. If a particle …