Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the develo** neuron. Regulation of polymer …

First described 15 years ago as a cysteine-rich sequence that was common to a small group
of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc …

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Memories become less precise and generalized over time as memory traces reorganize in
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …

The coelomocytes of Caenorhabditis elegans are scavenger cells that continuously and
nonspecifically endocytose fluid from the pseudocoelom (body cavity). Green fluorescent …

The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-
2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating …

Netrins promote axon outgrowth and turning through DCC/UNC-40 receptors. To
characterize Netrin signaling, we generated a gain-of-function UNC-40 molecule, MYR …

Organisms in the wild develop with varying food availability. During periods of nutritional
scarcity, development may slow or arrest until conditions improve. The ability to modulate …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …