Mobile genetic elements associated with antimicrobial resistance
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …
increasing major health care problem around the world. It is now abundantly clear that both …
The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria
During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have
become a substantial challenge to infection control. It has been suggested by clinicians that …
become a substantial challenge to infection control. It has been suggested by clinicians that …
Evolution of plasmid mobility: origin and fate of conjugative and nonconjugative plasmids
C Coluzzi, MP Garcillán-Barcia… - Molecular Biology …, 2022 - academic.oup.com
Conjugation drives the horizontal transfer of adaptive traits across prokaryotes. One-fourth of
the plasmids encode the functions necessary to conjugate autonomously, the others being …
the plasmids encode the functions necessary to conjugate autonomously, the others being …
Aminoglycoside modifying enzymes
Aminoglycosides have been an essential component of the armamentarium in the treatment
of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and …
of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and …
Antimicrobial resistance in the food chain: a review
C Verraes, S Van Boxstael, E Van Meervenne… - International journal of …, 2013 - mdpi.com
Antimicrobial resistant zoonotic pathogens present on food constitute a direct risk to public
health. Antimicrobial resistance genes in commensal or pathogenic strains form an indirect …
health. Antimicrobial resistance genes in commensal or pathogenic strains form an indirect …
Mobility of plasmids
Plasmids are key vectors of horizontal gene transfer and essential genetic engineering tools.
They code for genes involved in many aspects of microbial biology, including detoxication …
They code for genes involved in many aspects of microbial biology, including detoxication …
Intra-and interpopulation transposition of mobile genetic elements driven by antibiotic selection
The spread of genes encoding antibiotic resistance is often mediated by horizontal gene
transfer (HGT). Many of these genes are associated with transposons, a type of mobile …
transfer (HGT). Many of these genes are associated with transposons, a type of mobile …
Movement of IS 26-associated antibiotic resistance genes occurs via a translocatable unit that includes a single IS 26 and preferentially inserts adjacent to another IS …
The insertion sequence IS 26 plays a key role in disseminating antibiotic resistance genes in
Gram-negative bacteria, forming regions containing more than one antibiotic resistance …
Gram-negative bacteria, forming regions containing more than one antibiotic resistance …
The diversity of conjugative relaxases and its application in plasmid classification
MP Garcillán-Barcia, MV Francia… - FEMS microbiology …, 2009 - academic.oup.com
Bacterial conjugation is an efficient and sophisticated mechanism of DNA transfer among
bacteria. While mobilizable plasmids only encode a minimal MOB machinery that allows …
bacteria. While mobilizable plasmids only encode a minimal MOB machinery that allows …
Analysis of antibiotic resistance regions in Gram-negative bacteria
SR Partridge - FEMS microbiology reviews, 2011 - academic.oup.com
Antibiotic resistance in Gram-negative bacteria is often due to the acquisition of resistance
genes from a shared pool. In multiresistant isolates these genes, together with associated …
genes from a shared pool. In multiresistant isolates these genes, together with associated …