The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate
immune mechanism to monitor cellular damage and microbial invasion. Evading this …
immune mechanism to monitor cellular damage and microbial invasion. Evading this …
[HTML][HTML] Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
F Meng, Z Yu, D Zhang, S Chen, H Guan, R Zhou… - Molecular Cell, 2021 - cell.com
Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …
AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
Nutrient sensing and damage sensing are two fundamental processes in living organisms.
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …
IRF3 activates RB to authorize cGAS-STING–induced senescence and mitigate liver fibrosis
Q Wu, X Leng, Q Zhang, YZ Zhu, R Zhou, Y Liu… - Science …, 2024 - science.org
Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)–
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection
P Hou, K Yang, P Jia, L Liu, Y Lin, Z Li, J Li, S Chen… - Cell research, 2021 - nature.com
Autophagy is a conserved process that delivers cytosolic substances to the lysosome for
degradation, but its direct role in the regulation of antiviral innate immunity remains poorly …
degradation, but its direct role in the regulation of antiviral innate immunity remains poorly …
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
Y Lin, J Yang, Q Yang, S Zeng, J Zhang, Y Zhu… - Nature …, 2023 - nature.com
Abstract TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune
responses. While the oligomerization of TBK1 is critical for its full activation, the molecular …
responses. While the oligomerization of TBK1 is critical for its full activation, the molecular …
NLRC4 promotes the cGAS‐STING signaling pathway by facilitating CBL‐mediated K63‐linked polyubiquitination of TBK1
R Zhang, W Yang, H Zhu, J Zhai… - Journal of medical …, 2023 - Wiley Online Library
Abstract TANK‐binding kinase 1 (TBK1) is crucial in producing type Ⅰ interferons (IFN‐Ⅰ)
that play critical functions in antiviral innate immunity. The tight regulation of TBK1 …
that play critical functions in antiviral innate immunity. The tight regulation of TBK1 …
[HTML][HTML] Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases
The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …