Animal tissues are made up of multiple cell types that are increasingly well-characterized,
yet our understanding of the core principles that govern tissue organization is still …

Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics,
spatial proteomics, and computational approaches to define glioma cellular states and …

Cells execute biological functions to support phenotypes such as growth, migration, and
secretion. Complementarily, each function of a cell has resource costs that constrain …

Collective behaviour, social interactions and leadership in animal groups are often driven by
individual differences. However, most studies focus on same-species groups, in which …

Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved
ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide synthase inhibitor N [w] …

Tumors are complex ecosystems of interacting cell types. The concept of cancer hallmarks
distills this complexity into underlying principles that govern tumor growth. Here, we explore …

Combining 3D cultures such as tumor spheroids and organoids with spatial omics holds
great potential for tissue biology and cancer research. Yet, this potential is presently limited …

The influence of surface topography on stem cell behavior and differentiation has garnered
significant attention in regenerative medicine and tissue engineering. The cell-imprinting …

Adult stem cells occupy a niche that contributes to their function, but how stem cells rebuild
their microenvironment after injury remains an open‐ended question. Herein, biomaterial …

The application of single-cell molecular profiling coupled with spatial technologies has
enabled charting of cellular heterogeneity in reference tissues and in disease. This new …