Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …

Circular RNAs (circRNAs) are widespread circles of non-coding RNAs with largely unknown
function. Because stimulation of mammary cells with the epidermal growth factor (EGF) …

Inflammation is a fundamental innate immune response to perturbed tissue homeostasis.
Chronic inflammatory processes affect all stages of tumour development as well as therapy …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …

Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected
diversity in the mechanisms of their activation by growth factor ligands. Strategies for …

Multi-omics approaches are novel frameworks that integrate multiple omics datasets
generated from the same patients to better understand the molecular and clinical features of …

Th17 cells play a critical role in host defense against extracellular pathogens and tissue
homeostasis but can induce autoimmunity. The mechanisms implicated in balancing" …