Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies

P Smits, J Smeitink… - BioMed Research …, 2010 - Wiley Online Library
Mitochondrial disorders are a heterogeneous group of often multisystemic and early fatal
diseases, which are amongst the most common inherited human diseases. These disorders …

Roles of protein synthesis elongation factor EF‐Tu in heat tolerance in plants

J Fu, I Momčilović, PVV Prasad - Journal of Botany, 2012 - Wiley Online Library
EF‐Tu proteins of plastids, mitochondria, and the cytosolic counterpart EF‐1α in plants, as
well as EF‐Tu proteins of bacteria, are highly conserved and multifunctional. The functions …

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy

R Wang, Y Zhu, C Ren, S Yang, S Tian, H Chen, M **… - Autophagy, 2021 - Taylor & Francis
Influenza A virus (IAV) infection induces mitophagy, which is essential for the clearance of
damaged mitochondria. Dysfunctional mitochondria can be selectively targeted by PINK1 …

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy

Y Lei, H Wen, Y Yu, DJ Taxman, L Zhang, DG Widman… - Immunity, 2012 - cell.com
The mitochondrial protein MAVS (also known as IPS-1, VISA, and CARDIF) interacts with
RIG-I-like receptors (RLRs) to induce type I interferon (IFN-I). NLRX1 is a mitochondrial …

Comprehensive analysis of mitochondria in roots and hypocotyls of soybean under flooding stress using proteomics and metabolomics techniques

S Komatsu, A Yamamoto, T Nakamura… - Journal of Proteome …, 2011 - ACS Publications
Flooding is a serious problem for soybeans because it reduces growth and grain yield.
Proteomic and metabolomic techniques were used to examine whether mitochondrial …

The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple

R Che, C Liu, Q Wang, W Tu, P Wang, C Li, X Gong… - Autophagy, 2023 - Taylor & Francis
Macroautophagy/autophagy is a conserved degradation pathway in eukaryotes that is
required for recycling unwanted intracellular components, maintaining homeostasis, and …

Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis

W Weraarpachai, F Sasarman, T Nishimura… - The American Journal of …, 2012 - cell.com
We investigated a family in which the index subject presented with severe congenital lactic
acidosis and dysmorphic features associated with a cytochrome c oxidase (COX)-assembly …

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

J Cheng, Y Wang, L Yin, W Liang, J Zhang, C Ma… - Mbio, 2023 - Am Soc Microbiol
Mitochondria are good targets for viruses to manipulate their hosts. However, it remains
obscure whether respiratory syncytial virus (RSV) target mitochondria to suppress the type I …

A compendium of human mitochondrial gene expression machinery with links to disease

TE Shutt, GS Shadel - Environmental and molecular …, 2010 - Wiley Online Library
Mammalian mitochondrial DNA encodes 37 essential genes required for ATP production via
oxidative phosphorylation, instability or misregulation of which is associated with human …

When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases

LE González-Serrano, JW Chihade, M Sissler - Journal of Biological …, 2019 - ASBMB
Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are essential components of the
mitochondrial translation machinery. The correlation of mitochondrial disorders with …