The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality.
Although endothelial cells, being present in all organs as a single-cell layer, are often …

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Cellular senescence and the senescence‐associated secretory phenotype (SASP)
contribute to age‐related arterial dysfunction, in part, by promoting oxidative stress and …

Vascular aging encompasses structural and functional changes in the vasculature,
significantly contributing to cardiovascular diseases, which are the leading cause of death …

Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders.
Controlled removal of damaged mitochondria by the autophagic machinery, a process …

Cardiac ageing is an intricate and multifaceted process with considerable impact on public
health, especially given the global demographic shift towards aged populations. This review …

The theory that oxidative damage caused by mitochondrial free radicals leads to aging has
brought mitochondria into the forefront of aging research. Psychological stress that …

As the global demographic landscape continues to shift towards an aged population, so
does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is …