Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

A new statistical method for estimating divergence dates of species from DNA sequence
data by a molecular clock approach is developed. This method takes into account effectively …

Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA
(mtDNA) in humans and chimpanzees, we developed a new mathematical method for …

Reconstructing phylogenies from intraspecific data (such as human mitochondrial DNA
variation) is often a challenging task because of large sample sizes and small genetic …

We present here a framework for the study of molecular variation within a single species.
Information on DNA haplotype divergence is incorporated into an analysis of variance …