Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Exceptional advances in molecular biology and genetic research have expedited cancer
drug development tremendously. The declared paradigm is the development …

Artificial intelligence-based protein structure prediction approaches have had a
transformative effect on biomolecular sciences. The predicted protein models in the …

INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …

Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are
directed at the active conformation or a variety of inactive conformations. While attempts …

With the rapid development of computational techniques and hardware, more rigorous and
precise theoretical models have been used to predict the binding affinities of a large number …

Effective targeted cancer therapeutic development depends upon distinguishing disease-
associated 'driver'mutations, which have causative roles in malignancy pathogenesis, from …

The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon
dimerization has eluded definition. We find that the EGFR kinase domain can be activated …

Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …

The surface comparison of different serine–threonine and tyrosine kinases reveals a set of
30 residues whose spatial positions are highly conserved. The comparison between active …