Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Over the last decades, numerous papers have appeared—and still are appearing—that
describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent …

Although the influence of protein binding (PB) on antibacterial activity has been reported for
many antibiotics and over many years, there is currently no standardization for …

As obesity continues to increase in prevalence throughout the world, it becomes important to
explore the effects that obesity has on antimicrobial disposition. Physiologic changes in …

For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

Objectives As morbidly obese patients are prone to surgical site infections, adequate blood
and subcutaneous tissue concentrations of prophylactic antibiotic agents during surgery are …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

Objective: To assess the relative strengths and weaknesses of carbapenems by considering
their microbiological, clinical, pharmacokinetics and pharmacokinetic/pharmacodynamic …

Introduction: Since the majority of bacterial infections occur at sites outside the bloodstream,
antibiotic tissue concentrations are of significant relevance to optimize treatment. The aim of …

During antibiotic drug development, media are frequently spiked with either serum/plasma
or protein supplements to evaluate the effect of protein binding. Usually, previously reported …