Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown
etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine …

Rat brain cannabinoid receptor (CB-1) was stably transfected into the murine tumor line AtT-
20 to study its coupling to inwardly rectifying potassium currents (Kir) and high voltage …

Migraine—an episodic headache—affects more than 10% of the general population.
Despite recent progress, drug therapy for preventing and treating migraine remains …

Ziconotide (PRIALT®) is a neuroactive peptide in the final stages of clinical development as
a novel non-opioid treatment for severe chronic pain. It is the synthetic equivalent of ω …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …