Insights into aldehyde dehydrogenase enzymes: a structural perspective
Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …
Exposing synonymous mutations
RC Hunt, VL Simhadri, M Iandoli, ZE Sauna… - Trends in Genetics, 2014 - cell.com
Synonymous codon changes, which do not alter protein sequence, were previously thought
to have no functional consequence. Although this concept has been overturned in recent …
to have no functional consequence. Although this concept has been overturned in recent …
The neural crest in cardiac congenital anomalies
A Keyte, MR Hutson - Differentiation, 2012 - Elsevier
This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …
Partitioning the heart: mechanisms of cardiac septation and valve development
CJ Lin, CY Lin, CH Chen, B Zhou, CP Chang - Development, 2012 - journals.biologists.com
Heart malformations are common congenital defects in humans. Many congenital heart
defects involve anomalies in cardiac septation or valve development, and understanding the …
defects involve anomalies in cardiac septation or valve development, and understanding the …
[HTML][HTML] Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …
Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells
The aldehyde dehydrogenase (ALDH) superfamily is composed of nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+)-dependent enzymes that catalyze the oxidation of …
dinucleotide (phosphate)(NAD (P)+)-dependent enzymes that catalyze the oxidation of …
[HTML][HTML] Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration
The mammalian hearts have the least regenerative capabilities among tissues and organs.
As such, heart regeneration has been and continues to be the ultimate goal in the treatment …
As such, heart regeneration has been and continues to be the ultimate goal in the treatment …
Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …
Utilization of whole exome sequencing to identify causative mutations in familial congenital heart disease
Background—Congenital heart disease (CHD) is the most common type of birth defect with
family-and population-based studies supporting a strong genetic cause for CHD. The goal of …
family-and population-based studies supporting a strong genetic cause for CHD. The goal of …
[HTML][HTML] Mechanisms of retinoic acid signaling during cardiogenesis
S Stefanovic, S Zaffran - Mechanisms of development, 2017 - Elsevier
Substantial experimental and epidemiological data have highlighted the interplay between
nutritional and genetic factors in the development of congenital heart defects. Retinoic acid …
nutritional and genetic factors in the development of congenital heart defects. Retinoic acid …