Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton

K Sheng, Y Song, F Lei, W Zhao, L Fan, L Wu… - European journal of …, 2022 - Elsevier
The tetralone and tetralone derivatives, as crucial structural scaffolds of potential novel
drugs targeted at multiple biological end-points, are normally found in several natural …

Chemically engineered exogenous organic reactions in living cells for in situ fluorescence imaging and biomedical applications

G Song, Z Yang, Y Huang, H Bai, F Lv… - Journal of Materials …, 2024 - pubs.rsc.org
The unique microenvironment within living cells, characterized by high glutathione levels,
reactive oxygen species concentrations, and active enzymes, facilitates the execution of …

Bioactivity of selenium‐containing pyridinium salts: Prospecting future pharmaceutical constituents to treat liver diseases involving oxidative stress

ET Castro, AG Alves… - … of Biochemical and …, 2024 - Wiley Online Library
Redox imbalance leads to oxidative stress that causes irreversible cellular damage. The
incorporation of the antioxidant element selenium (Se) in the structure of pyridinium salts …

Fluorescent probes for detecting and imaging mitochondrial hydrogen sulfide

YW Zhu, EE Ngowi, AQ Tang, T Chu, Y Wang… - Chemico-Biological …, 2025 - Elsevier
Hydrogen sulfide (H 2 S) is a potent redox-active signaling molecule commonly
dysregulated in disease states. The production of H 2 S and its involvement in various …

Synthesis of CuI-modified thiol-functionalized MCM-41 silica-based materials and their catalytic tetralin performance

C Wu, Y Li, Y Ma, Y Lei, M Wang, Z Chen - Journal of Porous Materials, 2024 - Springer
A novel loaded copper ion catalyst, Cu/MCM-41-SH, was synthesized using CuI-modified
thiol-functionalized MCM-41 silica-based materials, and the prepared catalysts were …

Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment

M Abdel‐Motaal, DA Aldakhili… - Drug Development …, 2024 - Wiley Online Library
Although various approaches exist for treating cancer, chemotherapy continues to hold a
prominent role in the management of this disease. Besides, microtubules serve as a vital …

[PDF][PDF] Synthesis and biological evaluation of some new imidazo [1, 2-c] pyrimido [5, 4-e] pyrimidin-5-amine derivatives.

RJ Obaid - Umm Al-Qura University Journal of Applied Sciences, 2021 - researchgate.net
The pyrimidine ring is a skeleton of particular interest that it is present in many compounds
exhibiting biological and pharmaceutical activity. In the present work, some new pyrimidine …

A series of D-π-A and A-π-A'fluorescent probes were used to explore the influence of terminal groups on the properties of the hemicyanine probes

W Sun, G Hu, W Shen, H Xu, Z Deng, G Zhao… - Journal of Molecular …, 2021 - Elsevier
Based on the addition reaction of sulfur dioxide derivatives and Cdouble bondC, a series of
D-π-A and A-π-A'fluorescent probes were designed by combining different electronic groups …

Polymethine cyanine dyes: Synthesis, cytotoxic activity, and molecular docking study

AA Fadda, ER El-Sawy, RE El-Mekawy - Journal of Molecular Structure, 2023 - Elsevier
Virtually, an efficient synthetic procedure was adapted to synthesize new methine cyanine
dyes 3–22 from N-arenium salt 2 which was synthesized from the reaction of 1, 6 …

Role of enaminonitriles in heterocyclic synthesis: synthesis of some new aminothiazole derivatives against prostate carcinoma

AA Fadda, M Abd El Salam, Y Tag… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Among sulfur-and nitrogen-containing heterocyclic compounds, the aminothiazole scaffold
is one of the most unique architectures in drug development, since it comprises a variety of …