Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …

Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

The increasing importance of in vitro-transcribed (IVT) mRNA for synthesizing the encoded
therapeutic protein in vivo demands the manufacturing of pure mRNA products. The major …

To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …

Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …