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The nonribosomal peptide valinomycin: From discovery to bioactivity and biosynthesis
Valinomycin is a nonribosomal peptide that was discovered from Streptomyces in 1955.
Over the past more than six decades, it has received continuous attention due to its special …
Over the past more than six decades, it has received continuous attention due to its special …
Friedelin and 3β-friedelinol: pharmacological activities
The interest in herbal medicine as a source of drug leads is being reinforced, especially for
tackling challenging therapeutic areas such as antimicrobial resistance, cardiovascular …
tackling challenging therapeutic areas such as antimicrobial resistance, cardiovascular …
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study
YY Gu, M Zhang, H Cen, YF Wu, Z Lu, F Lu, XS Liu… - PloS one, 2021 - journals.plos.org
Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with
SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with …
SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with …
Multidisciplinary approaches identify compounds that bind to human ACE2 or SARS-CoV-2 spike protein as candidates to block SARS-CoV-2–ACE2 receptor …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus
that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein …
that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein …
[HTML][HTML] Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/3CLpro: molecular docking and simulation studies of three pertinent medicinal …
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and …
coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and …
Unlocking the microbial studies through computational approaches: how far have we reached?
The metagenomics approach accelerated the study of genetic information from uncultured
microbes and complex microbial communities. In silico research also facilitated an …
microbes and complex microbial communities. In silico research also facilitated an …
Host-directed therapy, an untapped opportunity for antimalarial intervention
Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases
caused by viruses and intracellular bacteria, but its implementation in the context of parasitic …
caused by viruses and intracellular bacteria, but its implementation in the context of parasitic …
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 In Vitro
Antivirals targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could
improve treatment of COVID-19. We evaluated the efficacy of clinically relevant hepatitis C …
improve treatment of COVID-19. We evaluated the efficacy of clinically relevant hepatitis C …
Computational investigation of potent inhibitors against SARS-CoV-2 2′-O-methyltransferase (nsp16): Structure-based pharmacophore modeling, molecular docking …
L Shi, Z Wen, Y Song, J Wang, D Yu - Journal of Molecular Graphics and …, 2022 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, has created unprecedented public health …
syndrome coronavirus 2 (SARS-CoV-2) infection, has created unprecedented public health …
Protein kinase CK2 and SARS-CoV-2: An expected interplay story
CP Quezada Meza, M Ruzzene - Kinases and Phosphatases, 2023 - mdpi.com
Protein kinase CK2 is a Ser/Thr protein kinase that phosphorylates hundreds of substrates
mainly related to survival and proliferation pathways. It has long been considered an anti …
mainly related to survival and proliferation pathways. It has long been considered an anti …