Circular RNA and its mechanisms in disease: from the bench to the clinic

B Han, J Chao, H Yao - Pharmacology & therapeutics, 2018 - Elsevier
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise
to a new perspective regarding our understanding of cellular physiology and disease …

CircRNA: a rising star in gastric cancer

R Li, J Jiang, H Shi, H Qian, X Zhang, W Xu - Cellular and Molecular Life …, 2020 - Springer
In recent years, a large number of circRNAs have been identified in mammalian cells with
high-throughput sequencing technologies and bioinformatics. The aberrant expression of …

circRNA_0025202 regulates tamoxifen sensitivity and tumor progression via regulating the miR-182-5p/FOXO3a axis in breast cancer

Y Sang, B Chen, X Song, Y Li, Y Liang, D Han… - Molecular Therapy, 2019 - cell.com
Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor
(HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually …

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

M Su, Y **ao, J Ma, Y Tang, B Tian, Y Zhang, X Li… - Molecular cancer, 2019 - Springer
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability.
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …

Emerging role of non‐coding RNA in health and disease

GK Bhatti, N Khullar, IS Sidhu, US Navik… - Metabolic brain …, 2021 - Springer
Human diseases have always been a significant turf of concern since the origin of mankind.
It is cardinal to know the cause, treatment, and cure for every disease condition. With the …

Role of circular RNAs in brain development and CNS diseases

SL Mehta, RJ Dempsey, R Vemuganti - Progress in neurobiology, 2020 - Elsevier
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood–brain …

Y Bai, Y Zhang, B Han, L Yang, X Chen… - Journal of …, 2018 - Soc Neuroscience
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and
pathophysiological processes. However, the potential role of circRNAs in stroke remains …

Molecular roles and function of circular RNAs in eukaryotic cells

LM Holdt, A Kohlmaier, D Teupser - Cellular and Molecular Life Sciences, 2018 - Springer
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …

A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1

B Zhou, JW Yu - Biochemical and biophysical research communications, 2017 - Elsevier
Circular RNAs (circRNAs) are a novel type of endogenous noncoding RNA gaining research
interest in recent years. Despite this increase in interest, the mechanism of circRNAs in the …

Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

S Najafi, SMA Zarch, J Majidpoor, S Pordel… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs) are a novel class of non-coding RNAs. They are single-stranded
RNA transcripts characterized with a closed loop structure making them resistant to …