Multiplexed imaging in oncology

C Andreou, R Weissleder, MF Kircher - Nature Biomedical Engineering, 2022 - nature.com
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems

CO Silva, JO Pinho, JM Lopes, AJ Almeida, MM Gaspar… - Pharmaceutics, 2019 - mdpi.com
Theranostics has emerged in recent years to provide an efficient and safer alternative in
cancer management. This review presents an updated description of nanotheranostic …

[HTML][HTML] Enhancing RNA-lipid nanoparticle delivery: organ-and cell-specificity and barcoding strategies

PS Wei, N Thota, G John, E Chang, S Lee… - Journal of Controlled …, 2024 - Elsevier
Recent advancements in RNA therapeutics highlight the critical need for precision gene
delivery systems that target specific organs and cells. Lipid nanoparticles (LNPs) have …

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

N Raval, R Maheshwari, H Shukla, K Kalia… - Materials Science and …, 2021 - Elsevier
Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …

Multifunctional polysaccharide nanoprobes for biological imaging

J Ju, D Xu, X Mo, J Miao, L Xu, G Ge, X Zhu… - Carbohydrate …, 2023 - Elsevier
Imaging and tracking biological targets or processes play an important role in revealing
molecular mechanisms and disease states. Bioimaging via optical, nuclear, or magnetic …

Recent progresses in the development of hyaluronic acid-based nanosystems for tumor-targeted drug delivery and cancer imaging

HJ Cho - Journal of pharmaceutical investigation, 2020 - Springer
Background Hyaluronic acid (HA) has been widely used as one of major components of
nanocarriers for cancer imaging and therapy. HA possesses hydrophilic and anionic …

68Ga-THP-PSMA: a PET imaging agent for prostate cancer offering rapid, room-temperature, 1-step kit-based radiolabeling

JD Young, V Abbate, C Imberti… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The clinical impact and accessibility of 68Ga tracers for the prostate-specific membrane
antigen (PSMA) and other targets would be greatly enhanced by the availability of a simple …

A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer

DR Vogus, MA Evans, A Pusuluri, A Barajas… - Journal of Controlled …, 2017 - Elsevier
Combination chemotherapy is commonly used to treat advanced breast cancer. However,
treatment success is often limited due to systemic toxicity. To improve therapeutic efficacy …

Polymer-drug conjugates as nanotheranostic agents

S Manandhar, E Sjöholm, J Bobacka… - Journal of …, 2021 - mdpi.com
Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of
the most promising drug-delivery technologies owing to several benefits like circumventing …

Design of bio-responsive hyaluronic acid–doxorubicin conjugates for the local treatment of glioblastoma

A Malfanti, G Catania, Q Degros, M Wang, M Bausart… - Pharmaceutics, 2022 - mdpi.com
Glioblastoma is an unmet clinical need. Local treatment strategies offer advantages, such as
the possibility to bypass the blood–brain barrier, achieving high drug concentrations at the …