Exploration, inference, and prediction in neuroscience and biomedicine
Recent decades have seen dramatic progress in brain research. These advances were
often buttressed by probing single variables to make circumscribed discoveries, typically …
often buttressed by probing single variables to make circumscribed discoveries, typically …
Annual Research Review: Translational machine learning for child and adolescent psychiatry
Children and adolescents could benefit from the use of predictive tools that facilitate
personalized diagnoses, prognoses, and treatment selection. Such tools have not yet been …
personalized diagnoses, prognoses, and treatment selection. Such tools have not yet been …
The druggable genome and support for target identification and validation in drug development
Target identification (determining the correct drug targets for a disease) and target validation
(demonstrating an effect of target perturbation on disease biomarkers and disease end …
(demonstrating an effect of target perturbation on disease biomarkers and disease end …
Improving the odds of drug development success through human genomics: modelling study
Lack of efficacy in the intended disease indication is the major cause of clinical phase drug
development failure. Explanations could include the poor external validity of pre-clinical …
development failure. Explanations could include the poor external validity of pre-clinical …
Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study
R Ahn, A Woodbridge, A Abraham, S Saba… - bmj, 2017 - bmj.com
Objective To examine the association between the presence of individual principal
investigators' financial ties to the manufacturer of the study drug and the trial's outcomes …
investigators' financial ties to the manufacturer of the study drug and the trial's outcomes …
On the predictive utility of animal models of osteoarthritis
Animal models of osteoarthritis are extensively used for investigating disease pathways and
for preclinical testing of novel therapies. Their predictive utility, however, has often been …
for preclinical testing of novel therapies. Their predictive utility, however, has often been …
Wasted research when systematic reviews fail to provide a complete and up-to-date evidence synthesis: the example of lung cancer
P Créquit, L Trinquart, A Yavchitz, P Ravaud - BMC medicine, 2016 - Springer
Background Multiple treatments are frequently available for a given condition, and clinicians
and patients need a comprehensive, up-to-date synthesis of evidence for all competing …
and patients need a comprehensive, up-to-date synthesis of evidence for all competing …
Evaluation of drug trials in high-, middle-, and low-income countries and local commercial availability of newly approved drugs
Importance Clinical research supporting US Food and Drug Administration (FDA) drug
approvals is largely conducted outside the US. Objective To characterize where drugs were …
approvals is largely conducted outside the US. Objective To characterize where drugs were …
[HTML][HTML] Age and sex in drug development and testing for adults
C Tannenbaum, D Day - Pharmacological research, 2017 - Elsevier
Individualization of drug therapy requires that the right drug be administered at the correct
dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex …
dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex …
Risk of amputations associated with SGLT2 inhibitors compared to DPP‐4 inhibitors: a propensity‐matched cohort study
Aim To determine the risk of amputations associated with sodium‐glucose co‐transporter‐2
inhibitors (SGLT2i) relative to dipeptidyl peptidase‐4 inhibitors (DPP4i). Materials and …
inhibitors (SGLT2i) relative to dipeptidyl peptidase‐4 inhibitors (DPP4i). Materials and …