The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Mitochondrial DNA release in innate immune signaling
According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
N Miao, Z Wang, Q Wang, H **e, N Yang… - Nature …, 2023 - nature.com
Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
Regulation of cGAS-and RLR-mediated immunity to nucleic acids
A Ablasser, S Hur - Nature immunology, 2020 - nature.com
Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …
structural similarity between those and host nucleic acids, mammalian cells have been able …