Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects
S Di Bella, P Ascenzi, S Siarakas, N Petrosillo… - Toxins, 2016 - mdpi.com
Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …
The “beauty in the beast”—the multiple uses of Priestia megaterium in biotechnology
Over 30 years, the Gram-positive bacterium Priestia megaterium (previously known as
Bacillus megaterium) was systematically developed for biotechnological applications …
Bacillus megaterium) was systematically developed for biotechnological applications …
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
Cytosolic inflammasome complexes mediated by a pattern recognition receptor (PRR)
defend against pathogen infection by activating caspase 1. Pyrin, a candidate PRR, can …
defend against pathogen infection by activating caspase 1. Pyrin, a candidate PRR, can …
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases
associated with C. difficile infection. Here we carried out CRISPR–Cas9-mediated genome …
associated with C. difficile infection. Here we carried out CRISPR–Cas9-mediated genome …
Rapid acquisition and model-based analysis of cell-free transcription–translation reactions from nonmodel bacteria
Native cell-free transcription–translation systems offer a rapid route to characterize the
regulatory elements (promoters, transcription factors) for gene expression from nonmodel …
regulatory elements (promoters, transcription factors) for gene expression from nonmodel …
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
P Chen, JI Zeng, Z Liu, H Thaker, S Wang… - Nature …, 2021 - nature.com
C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile
exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and …
exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and …
Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
As a gram-positive, spore-forming anaerobic bacillus, Clostridium difficile (C. difficile) is
responsible for severe and fatal pseudomembranous colitis, and poses the most urgent …
responsible for severe and fatal pseudomembranous colitis, and poses the most urgent …
A probiotic yeast-based immunotherapy against Clostridioides difficile infection
K Chen, Y Zhu, Y Zhang, T Hamza, H Yu… - Science translational …, 2020 - science.org
Antibiotic-resistant Clostridioides difficile is an anaerobic Gram-positive bacterium that
colonizes the colon and is responsible for more than 29,000 deaths in the United States …
colonizes the colon and is responsible for more than 29,000 deaths in the United States …
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Clostridium difficile infection is the most common cause of antibiotic-associated diarrhea in
developed countries. The major virulence factor, C. difficile toxin B (TcdB), targets colonic …
developed countries. The major virulence factor, C. difficile toxin B (TcdB), targets colonic …
Clostridium difficile toxin–induced inflammation and intestinal injury are mediated by the inflammasome
BACKGROUND & AIMS: Clostridium difficile–associated disease (CDAD) is the leading
cause of nosocomial diarrhea in the United States. C difficile toxins TcdA and TcdB breach …
cause of nosocomial diarrhea in the United States. C difficile toxins TcdA and TcdB breach …