Imaging in the era of molecular oncology

R Weissleder, MJ Pittet - Nature, 2008 - nature.com
New technologies for imaging molecules, particularly optical technologies, are increasingly
being used to understand the complexity, diversity and in vivo behaviour of cancers.'Omic' …

Photoresponsive nanoparticles for drug delivery

AY Rwei, W Wang, DS Kohane - Nano today, 2015 - Elsevier
Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic
agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy …

Scanner-free and wide-field endoscopic imaging by using a single multimode optical fiber

Y Choi, C Yoon, M Kim, TD Yang, C Fang-Yen… - Physical review …, 2012 - APS
A single multimode fiber is considered an ideal optical element for endoscopic imaging due
to the possibility of direct image transmission via multiple spatial modes. However, the wave …

Eliminating illumination crosstalk while using multiple imaging devices with plural scanning devices, each coupled to an optical fiber

R Johnston, E Seibel, CD Melville - US Patent 7,791,009, 2010 - Google Patents
(57) ABSTRACT A system includes a plurality of Scanning devices and light receivers,
enabling a plurality of images of a site to be dis played using output signals produced in …

Photoswitchable nanoparticles for in vivo cancer chemotherapy

R Tong, HH Chiang… - Proceedings of the …, 2013 - National Acad Sciences
There are many obstacles to effective cancer chemotherapy, including drug penetration and
accumulation in tumors and drug systemic toxicity. The penetration of therapies into tumors …

Optical fibers for high-resolution in vivo microendoscopic fluorescence imaging

G Oh, E Chung, SH Yun - Optical Fiber Technology, 2013 - Elsevier
Optical fiber-based high-resolution fluorescence imaging techniques have promising
applications in clinical practice and preclinical research using animals. Here we review the …

Subcellular-resolution molecular imaging within living tissue by fiber microendoscopy

TJ Muldoon, MC Pierce, DL Nida, MD Williams… - Optics express, 2007 - opg.optica.org
Conventional histopathology involves sampling, sectioning and staining of tissue specimens
prior to microscopic evaluation, and provides diagnostic information at a single location and …

Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy

GA Sonn, SNE Jones, TV Tarin, CB Du, KE Mach… - The Journal of …, 2009 - Elsevier
PURPOSE: Confocal laser endomicroscopy is a new endoscopic imaging technology that
could complement white light cystoscopy by providing in vivo bladder histopathology. We …

Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

BQ Spring, AO Abu-Yousif… - Proceedings of the …, 2014 - National Acad Sciences
Drug-resistant micrometastases that escape standard therapies often go undetected until the
emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic …

Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion (s)

GJ Tearney, BE Bouma, D Yelin - US Patent 8,838,213, 2014 - Google Patents
Exemplary apparatus and process can be provided for imaging information associated with
at least one portion of a sample. For example,(i) at least two first different wavelengths of at …