Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - journals.asm.org
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Aspergillus fumigatus morphology and dynamic host interactions

FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Defining physiological normoxia for improved translation of cell physiology to animal models and humans

TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Pathogenicity and virulence of Aspergillus fumigatus

K Earle, C Valero, DP Conn, G Vere, PC Cook… - Virulence, 2023 - Taylor & Francis
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Aspergillus fumigatus and aspergillosis: from basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

[HTML][HTML] Exploring the genomic diversity of black yeasts and relatives (Chaetothyriales, Ascomycota)

MM Teixeira, LF Moreno, BJ Stielow, A Muszewska… - Studies in mycology, 2017 - Elsevier
Abstract The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily
melanised fungi and includes numerous etiologic agents of chromoblastomycosis …

Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance

CH Kowalski, KA Morelli, D Schultz, CD Nadell… - Proceedings of the …, 2020 - pnas.org
Human fungal infections may fail to respond to contemporary antifungal therapies in vivo
despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro …

Antifungal therapy: Novel drug delivery strategies driven by new targets

S Wu, R Song, T Liu, C Li - Advanced Drug Delivery Reviews, 2023 - Elsevier
In patients with compromised immunity, invasive fungal infections represent a significant
cause of mortality. Given the limited availability and drawbacks of existing first-line antifungal …

ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

D Chung, BM Barker, CC Carey, B Merriman… - PLoS …, 2014 - journals.plos.org
The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs
to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for …