Psychedelics are undergoing a major resurgence of scientific and clinical interest. While
multiple theories and frameworks have been proposed, there is yet no universal agreement …

Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Visual processing is dynamically controlled by multiple neuromodulatory molecules that
modify the responsiveness of neurons and the strength of the connections between them. In …

We developed a family of genetically encoded serotonin (5-HT) sensors (sDarken) on the
basis of the native 5-HT1A receptor and circularly permuted GFP. sDarken 5-HT sensors are …

Rich spatiotemporal dynamics of cortical activity, including complex and diverse wave
patterns, have been identified during unconscious and conscious brain states. Yet, how …

Response gain is a crucial means by which modulatory systems control the impact of
sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such …

Accurate measures of contrast sensitivity are important for evaluating visual disease
progression and for navigation safety. Previous measures suggested that cortical contrast …

Neuroscience and artificial intelligence (AI) share a long history of collaboration. Advances
in neuroscience, alongside huge leaps in computer processing power over the last few …

Serotonergic neurons constitute one of the main systems of neuromodulators, whose diffuse
projections regulate the functions of the cerebral cortex. Serotonin (5-HT) is known to play a …

Abstract N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A
serotonin receptors, which is associated with intense visual hallucinatory phenomena and …