Tissue-specific macrophages: how they develop and choreograph tissue biology

E Mass, F Nimmerjahn, K Kierdorf… - Nature Reviews …, 2023 - nature.com
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Pyroptosis: mechanisms and diseases

P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

Apoptosis, pyroptosis, and necroptosis—Oh my! The many ways a cell can die

N Ketelut-Carneiro, KA Fitzgerald - Journal of molecular biology, 2022 - Elsevier
Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

[HTML][HTML] Overview and update on extracellular vesicles: considerations on exosomes and their application in modern medicine

MA Di Bella - Biology, 2022 - mdpi.com
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized
particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular …

[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …

J Boren, MJ Chapman, RM Krauss… - European heart …, 2020 - academic.oup.com
OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

The clearance of dead cells by efferocytosis

E Boada-Romero, J Martinez, BL Heckmann… - … reviews Molecular cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Detection of immunogenic cell death and its relevance for cancer therapy

J Fucikova, O Kepp, L Kasikova, G Petroni… - Cell death & …, 2020 - nature.com
Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically
relevant tumor-targeting immune responses, which critically rely on the antigenicity of …

Efferocytosis in health and disease

AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …