Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the
body signal transduction mechanisms involved in inflammation, differentiation, proliferation …

Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-
block copolymers of poly (ethylene oxide) and poly (propylene oxide)(PEO-PPO-PEO) have …

Osteosarcoma is the most frequent primary bone tumor that develops mainly in the young,
the median age of diagnosis being 18 years. Despite improvement in osteosarcoma …

Objective: The voltage-gated KCNQ1 potassium channel regulates key physiological
functions in a number of tissues. In the heart, KCNQ1 α-subunits assemble with KCNE1 β …

Finding suitable nonviral delivery vehicles for nucleic acid–based therapeutics is a landmark
goal in gene therapy. Cell-penetrating peptides (CPPs) are one class of delivery vectors that …

Polyethylenimine (PEI), a cationic polymer, has been widely studied and shown great
promise as an efficient gene delivery vehicle. Likewise, the HIV-1 Tat peptide, a cell …

Amphiphilic block copolymers of poly (ethylene oxide) and poly (propylene oxide) called
Pluronic or poloxamer are commercially available pharmaceutical excipients. They recently …

Systemic gene delivery systems are needed for therapeutic application to organs that are
inaccessible by percutaneous injection. Currently, the main objective is the development of …

Naked plasmid DNA (pDNA)-based gene therapy has low delivery efficiency, and
consequently, low therapeutic effect. We present a biodegradable nonionic triblock …

Since the legendary 1964 article of Folkman and Long entitled “The use of silicone rubber
as a carrier for prolonged drug therapy” the role of polymers in controlled drug delivery has …