BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor
protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within …

Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate
the action potential in electrically excitable cells. They are a major focus of research in …

Upregulation of functional voltage-gated Na+ channels (VGSCs) occurs in metastatic human
breast cancer (BCa) in vitro and in vivo. The present study aimed to ascertain the specific …

BACE1 is required for the release of β-amyloid (Aβ) in vivo, and inhibition of BACE1 activity
is targeted for reducing Aβ generation in Alzheimer's patients. To further our understanding …

BACKGROUND: Approximately 10% of sudden infant death syndrome (SIDS) cases may
stem from potentially lethal cardiac channelopathies, with approximately half of …

Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation,
supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the …

The vertebrate sodium (Na v) channel is composed of an ion-conducting α subunit and
associated β subunits. Here, we report the crystal structure of the human β3 subunit …

The voltage‐gated sodium channel NaV1. 7 is involved in various pain phenotypes and is
physiologically regulated by the NaV‐β3‐subunit. Venom toxins ProTx‐II and OD1 modulate …

Aims Loss-of-function mutations in the SCN5A-encoded sodium channel SCN5A or Nav1. 5
have been identified in idiopathic ventricular fibrillation (IVF) in the absence of Brugada …

In cardiac myocytes, the voltage‐gated sodium channel NaV1. 5 opens in response to
membrane depolarisation and initiates the action potential. The NaV1. 5 channel is typically …