Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …

Human schistosomiasis—or bilharzia—is a parasitic disease caused by trematode flukes of
the genus Schistosoma. By conservative estimates, at least 230 million people worldwide …

There is a wealth of immunologic studies that have been carried out in experimental and
human schistosomiasis that can be classified into three main areas: immunopathogenesis …

Granulomas are organized aggregates of macrophages, often with characteristic
morphological changes, and other immune cells. These evolutionarily ancient structures …

The parasitic worms, Schistosoma mansoni and Schistosoma japonicum, reside in the
mesenteric veins, where they release eggs that induce a dramatic granulomatous response …

Objective: To investigate and measure the functional significance of altered P2Y12
expression in the context of human microglia activation. Methods: We performed in vitro and …

Schistosomes are long lived, intravascular parasitic platyhelminths that infect> 200 million
people globally. The molecular mechanisms used by these blood flukes to dampen host …

The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Background Female genital schistosomiasis (FGS) affects up to 56 million women in sub-
Saharan Africa and may increase risk of HIV infection. Methods To assess the association of …

CRISPR/Cas9-based genome editing has yet to be reported in species of the
Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma …